Identifying mutant pathways in the histiocytoses.
نویسنده
چکیده
In this issue of Blood, the findings of Chakraborty et al and Emile et al support a model in which the mitogen-activated protein kinase (MAPK) and PI3K/AKT pathways are critical in the pathogenesis of 2 of the most common histiocytoses—Langerhans cell histiocytosis (LCH) and Erdheim-Chester disease (ECD)—whereas their respective mutational profiles demonstrate important similarities and differences.
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ورودعنوان ژورنال:
- Blood
دوره 124 19 شماره
صفحات -
تاریخ انتشار 2014